Journal: Pain
Article Title: Long-term neuropathic pain behaviors correlate with synaptic plasticity and limbic circuit alteration: a comparative observational study in mice
doi: 10.1097/j.pain.0000000000002549
Figure Lengend Snippet: Gene expression profile comparison between SNI and sham mice coupled by brain area and injury duration. (A, C, E, and G) Show the heatmap summarizing the global and distinct gene expression levels across the screening sets in hippocampus (A) or PFC (C) of the 1-month SNI mice compared with sham animals and in hippocampus (E) or PFC (G) of the 12-month SNI mice compared with sham animals. The heatmaps were profiled based on the results of low-density TaqMan-RT-qPCR array, and the analysis was performed using GraphPad Prism software (version 7.05). (B, D, F, and H) Show the expression levels of the significantly ( P < 0.05) deregulated genes between the 1-month SNI and sham mice at hippocampal region (B) or at PFC (D) and between the 12-month SNI and sham mice at hippocampal region (F) or at PFC (H). Data are expressed as the mean ± SD. PFC, prefrontal cortex; SNI, spared nerve injury.
Article Snippet: Heatmap was constructed using the statistical computing tool GraphPad Prism software (v7.05).
Techniques: Gene Expression, Comparison, Quantitative RT-PCR, Software, Expressing